Association of MBL2 polymorphism with Leg Ulcers Development in Sickle Cell Anemia Patients
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چکیده
منابع مشابه
Side Effects of Hydroxyurea in Patients with Sickle Cell Anemia
Background: Hemoglobin S arises is the result of a point mutation (A-T) in the sixth codon on the -globin gene on chromosome 11 causing sickle cell anemia. The presence of fetal hemoglobin in infancy plays a relatively protective role for vaso-occlusive symptoms that are the major contributor for the morbidity and mortality among patients with sickle cell anemia. hydroxyurea, an s-phase-specif...
متن کاملLow-Frequency Temperature Oscillations of Leg Ulcers in Patients with Sickle Cell Anemia
Infrared (IR) imaging and Laser Speckle Contrast Imaging (LSCI) were used to measure skin temperature and blood flow, respectively, in leg ulcers of sickle cell anemia patients. Regional maps of the power of oscillations were computed via Fast Fourier Transform within the ulcers and surrounding tissues. We hypothesize that measurements of regional oscillations of temperature and perfusion by IR...
متن کاملLeg ulcers in sickle cell disease.
Sickle cell disease is a single amino acid molecular disorder of hemoglobin leading to its pathological polymerization, red cell rigidity that causes poor microvascular blood flow, with consequent tissue ischemia and infarction. The manifestations of this disease are protean.Among them, leg ulcers represent a particularly disabling and chronic complication, often associated with a more severe c...
متن کاملSide effects of hydroxyurea in patients with Thalassemia major and thalassemia intermedia and sickle cell anemia
Background Sickle hemoglobin is the most common abnormal hemoglobin in the United States. Hemoglobin S arises as a result of a single amino acid substitution (glutamic acid to valin at position 6 of the β-globine chain). The presence of fetal hemoglobin (HbF) plays a relatively protective role since a significant amount of HbF interferes with HbS polymerization, the pathogenesis mechanism of ...
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ژورنال
عنوان ژورنال: Blood
سال: 2014
ISSN: 0006-4971,1528-0020
DOI: 10.1182/blood.v124.21.4912.4912